Neutrophilia

Neutrophilia (or neutrophil leukocytosis is a condition where a person has a high number of neutrophil granulocyte in their blood lt;/ref>

Causes

Neutrophils are the primary white blood cell that respond to a bacteria infection so the most common cause of neutrophilia is a bacterial infection, especially pyogenic infection . Table 12-6 in: 8th edition. Neutrophils are also increased in any acute inflammation so will be raised after a myocardial infarction lt;ref nameKumar12-6/>, other infarct or burn . Some drugs, such as prednisone have the same effect as cortisol causing marginated neutrophils to enter the blood stream. Anxiety will very slightly raise the neutrophil count because of this effect. A neutrophilia might also be the result of a Malignant Chronic myelogenous leukemia (CML or chronic myeloid leukaemia) is a disease where the blood cells proliferate out of control. These cells may be neutrophils. Neutrophilia can also be caused by appendicitis.

"Left shift"

A "left shift" refers to the presence of increased proportions of younger, less well differentiated neutrophils and neutrophil-precursor cells in the blood. This generally reflects early or premature release of myeloid cells from the bone marrow the site where neutrophils are generated. A severe neutrophilia with left shift is referred to as a leukemoid reaction The leukocyte alkaline phosphatase (LAP) score, which refers to the amount of alkaline phosphatase per neutrophil, will increase. In a severe infection, toxic granulation changes happen to the neutrophils. This can resemble Pelger-Huet anomaly lt;/ref>lt;/ref>

See also

*Granulocytosis (often used as synonym) *Neutropenia (having too few neutrophils) *Absolute neutrophil count

References

Category:Hematology de:Neutrophilie hr:Neutrofilija it:Neutrofilia pl:Neutrofilia pt:Neutrofilia

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